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Phenotypes Associated with This Genotype
Genotype
MGI:6430341
Allelic
Composition		 Lgr5tm1(cre/ERT2)Cle/Lgr5+
Mex3atm1.1(KOMP)Vlcg/Mex3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Mex3atm1.1(KOMP)Vlcg mutation (0 available); any Mex3a mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:287423 )
• 16% of mice exhibit postnatal lethality associated with disturbances in the intestinal epithelium

digestive/alimentary system
abnormal intestinal epithelium morphology ( J:287423 )
• disturbances in the intestinal epithelium
abnormal small intestine crypts of Lieberkuhn morphology ( J:287423 )
• loss of Lgr5+ intestinal stem cells in the intestine

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:287423 )
• loss of Lgr5+ intestinal stem cells in the intestine

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory