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Phenotypes Associated with This Genotype
Genotype
MGI:6423102
Allelic
Composition
Muc4tm1Unc/Muc4tm1Unc
Genetic
Background
B6NTac.129(FVB)-Muc4tm1Unc/Rand
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc4tm1Unc mutation (0 available); any Muc4 mutation (136 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice

respiratory system
• in female mice infected with SARS-CoV

growth/size/body
• female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice

immune system
• female mice infected with the recombinant mouse adapted SARS-CoV (rMA15) exhibit reduced body weight with some requiring euthanasia, reduced histopathological damage, more rapid exhalation, and more labored breathing compared with control or male mice
• however, mice exhibit normal viral load and male mice exhibit normal histopathological damage
• female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice
• mice infected with Chinkungunya virus exhibit augmented disease with early infection, displaying a biphasic swelling pattern more prominent in male mice compared with control mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:287566


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory