About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6415340
Allelic
Composition
Tg(FOXJ1-ACE2)1Rba/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(FOXJ1-ACE2)1Rba mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• SARS-CoV-2 infected mice that die show decreased lymphocyte numbers
• SARS-CoV-2-infected mice show different levels of pneumonia throughout the infection course
• at 1 dpi, mice show minor multifocal lesions in the lung, some thickening of alveolar walls with monocyte and lymphocyte infiltration and an increase in macrophages and lymphocytes in some alveolar spaces with minor exudation of fibrin
• at 3 dpi, moderate interstitial pneumonia is seen, with multifocal lesions, increased inflammatory cells at peri-bronchial and peri-vascular infiltration, and fibroblast hyperplasia with exudation of fibrin and protein edema in some alveoli
• after 5 dpi, 72.7% of mice show mild peri-bronchial and peri-vascular infiltration and 27.3% of mice show more severe pneumonia, with peri-bronchial and peri-vascular mixed inflammatory cell infiltration, fibroplasia, congestion, edema with hyaline membrane formation with some blocked terminal bronchioles and necrosis in some alveolar cells
• a subset of mice infected intranasally with SARS-CoV-2 show decreased body weight from days 4 to 6 post-infection, show noticeable respiratory distress and neurological symptoms (J:288386)
• however, a subset of SARS-CoV-2 infected mice survive to the endpoint of the study without symptoms (J:288386)
• viral RNA is detected in all lungs from 1 dpi with SARS-CoV-2 and increases slowly until 5 dpi and then decreases beginning 7 dpi; low levels of viral RNA is seen in the eyes and hearts of some of the mice (J:288386)
• viral antigens are seen in the bronchial epithelial cells and alveolar cells of the lungs (J:288386)
• deceased mice show viral antigens in the brain (J:288386)
• levels of neutrophils and monocytes begin to increase in the peripheral blood at day 1 of SARS-CoV-2 infection, peak at day 3, and decrease at 5-7 days post-infection (dpi) (J:288386)
• 10-20 week old mice infected with the bat SARS-like coronavirus WIV1 (WIV1-CoV), show increased susceptibility to infection compared to wild-type mice but less than when infected with SARS-CoV Urbani (J:287092)
• mice infected with WIV1-CoV, show minimal weight loss until late times when mice either lose less than or more than 10% of their body weight (J:287092)
• mice infected with WIV1-CoV show 100-fold higher titers than in wild-type mice (J:287092)
• all mice infected with SARS-CoV Urbani lose more than 20% body weight and maintain replication in the lung and brain following infection (J:287092)
• mice with more than 10% weight loss following WIV1-CoV infection produce robust viral replication in the brain, but lower titers in the lungs (J:287092)
• mice that maintain minimal weight less of less than 10% following WIV1-CoV infection show minimal titers in both the lung and brain after 7 days, indicating a sufficient adaptive immune response (J:287092)
• mice treated with antibody 227.14 one day before infection with either SARS-CoV or WIV1-CoV show no detectable virus in lungs (J:287092)
• mice infected with SARS-CoV-2 show 50% lethality (J:288386)
• 10-20 week old mice infected with SARS-CoV Urbani show rapid weight loss and death between days 4 and 5 of infection (J:287092)
• 10-20 week old mice infected with the bat SARS-like coronavirus WIV1 show an approximate 50% lethality by 7 days post infection (J:287092)
• mice treated with a monoclonal antibody derived from B cells from SARS-CoV-infected patients, antibody 227.14, one day before infection show protection from lethal SARS-CoV Urbani or WIV-CoV challenge (J:287092)

cellular
• SARS-CoV-2-infected mice that develop severe pneumonia show necrosis in some alveolar cells

cardiovascular system
• SARS-CoV-2-infected mice that develop severe pneumonia show pulmonary congestion
• SARS-CoV-2-infected mice show edema in some cardiomyocytes
• SARS-CoV-2-infected mice show several necrotic myocytes in heart tissue

mortality/aging
• mice infected with SARS-CoV-2 show 50% lethality (J:288386)
• 10-20 week old mice infected with SARS-CoV Urbani show rapid weight loss and death between days 4 and 5 of infection (J:287092)
• 10-20 week old mice infected with the bat SARS-like coronavirus WIV1 show an approximate 50% lethality by 7 days post infection (J:287092)
• mice treated with a monoclonal antibody derived from B cells from SARS-CoV-infected patients, antibody 227.14, one day before infection show protection from lethal SARS-CoV Urbani or WIV-CoV challenge (J:287092)

hematopoietic system
• SARS-CoV-2 infected mice that die show decreased lymphocyte numbers

homeostasis/metabolism
• SARS-CoV-2-infected mice that die show increased aspartate transaminase levels
• hyaline thrombus and fibrin are seen in severely SARS-CoV-2-infected lungs
• SARS-CoV-2-infected mice show higher levels of creatine kinase than control mice
• SARS-CoV2-infected mice that develop severe pneumonia exhibit edema

muscle
• SARS-CoV-2-infected mice show edema in some cardiomyocytes
• SARS-CoV-2-infected mice show several necrotic myocytes in heart tissue

respiratory system
• SARS-CoV-2-infected mice that develop severe pneumonia show pulmonary congestion
• SARS-CoV-2-infected mice that develop severe pneumonia show necrosis in some alveolar cells
• SARS-CoV2-infected mice that develop severe pneumonia exhibit edema
• SARS-CoV-2-infected mice show different levels of pneumonia throughout the infection course
• at 1 dpi, mice show minor multifocal lesions in the lung, some thickening of alveolar walls with monocyte and lymphocyte infiltration and an increase in macrophages and lymphocytes in some alveolar spaces with minor exudation of fibrin
• at 3 dpi, moderate interstitial pneumonia is seen, with multifocal lesions, increased inflammatory cells at peri-bronchial and peri-vascular infiltration, and fibroblast hyperplasia with exudation of fibrin and protein edema in some alveoli
• after 5 dpi, 72.7% of mice show mild peri-bronchial and peri-vascular infiltration and 27.3% of mice show more severe pneumonia, with peri-bronchial and peri-vascular mixed inflammatory cell infiltration, fibroplasia, congestion, edema with hyaline membrane formation with some blocked terminal bronchioles and necrosis in some alveolar cells
• a subset of mice infected with SARS-CoV-2 show respiratory distress


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory