Phenotypes Associated with This Genotype

Genotype
MGI:6415132

• Allelic Composition: Tg(CRYBB1-Loxl1)1Erta/0
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:267674 )

• the lens appears to be less transparent in some mice

• however, no other changes in eyes are seen compared to wild-type mice

abnormal lens fiber morphology ( J:267674 )

• electron-dense round or oval bodies that are 20-50 nm in diameter are seen in the cytoplasm of lens fibers and in the posterior lens capsule at P10

• electron-dense bodies form clusters containing LOXL1 aggregates in the perinuclear cytoplasm of lens fibers surrounded by a membrane that contains ribosomes indicating aggregation of LOXL1 protein in the rough endoplasmic reticulum

• rough endoplasmic reticulum cisterns in lens fibers are dilated

abnormal intraocular pressure ( J:267674 )

• intraocular pressure is higher in 1 month old mice, but not at 2, 3, 4, or 5 months of age