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Phenotypes Associated with This Genotype
Genotype
MGI:6414961
Allelic
Composition
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (935 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

nervous system
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory