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Phenotypes Associated with This Genotype
Genotype
MGI:6414951
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:285841 )
• some mice fail to gain normal body weight and die before weaning

behavior/neurological
ataxia ( J:285841 )
• surviving mice show moderate ataxia

muscle
muscle spasm ( J:285841 )
• surviving mice show spasms when disrupted during rest

nervous system
abnormal glial cell physiology ( J:285841 )
• glial cells exhibit increased growth
abnormal brain development ( J:285841 )
• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated
abnormal brainstem morphology ( J:285841 )
• higher density of PDGFRA+ cells in brainstems

neoplasm
neoplasm ( J:285841 )
N
• mice do not develop tumors

cellular
abnormal glial cell physiology ( J:285841 )
• glial cells exhibit increased growth

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory