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Phenotypes Associated with This Genotype
Genotype
MGI:6414672
Allelic
Composition		 Nos1aptm1Tsso/Nos1aptm1Tsso
Tg(Prnp-MAPT*P301S)PS19Vle/0
Genetic
Background		 involves: C57BL/6 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1aptm1Tsso mutation (0 available); any Nos1ap mutation (31 available)
Tg(Prnp-MAPT*P301S)PS19Vle mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:278451 )
N
• mice show reduced levels of total and phosphorylated tau and a reduction of Sarkosyl-insoluble tau indicating reduced tau pathology and ameliorated brain atrophy and neuron loss

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory