Phenotypes Associated with This Genotype

Genotype
MGI:6408604

• Allelic Composition: Rabgap1^{tm1b(EUCOMM)Hmgu}/Rabgap1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Rabgap1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0553_3_H04

Data Sources

IMPC Data for Rabgap1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - HMGU

abnormal gait ( J:211773 )

♀

IMPC - HMGU

decreased locomotor activity ( J:211773 )

IMPC - HMGU

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

endocrine/exocrine glands

small testis ( J:211773 )

♂

IMPC - HMGU

growth/size/body

polycystic kidney ( J:211773 )

♀

IMPC - HMGU

enlarged urinary bladder ( J:211773 )

♂

IMPC - HMGU

enlarged spleen ( J:211773 )

♀

IMPC - HMGU

hematopoietic system

enlarged spleen ( J:211773 )

♀

IMPC - HMGU

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

♀

IMPC - HMGU

decreased effector memory T-helper cell number ( J:211773 )

♀

IMPC - HMGU

small spleen ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating lipase level ( J:211773 )

♂

IMPC - HMGU

decreased circulating total protein level ( J:211773 )

IMPC - HMGU

improved glucose tolerance ( J:211773 )

♂

IMPC - HMGU

immune system

enlarged spleen ( J:211773 )

♀

IMPC - HMGU

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

♀

IMPC - HMGU

decreased effector memory T-helper cell number ( J:211773 )

♀

IMPC - HMGU

small spleen ( J:211773 )

♂

IMPC - HMGU

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - HMGU

nervous system

hydrocephaly ( J:211773 )

♀

IMPC - HMGU

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

decreased prepulse inhibition ( J:211773 )

♂

IMPC - HMGU

renal/urinary system

polycystic kidney ( J:211773 )

♀

IMPC - HMGU

enlarged urinary bladder ( J:211773 )

♂

IMPC - HMGU

reproductive system

small testis ( J:211773 )

♂

IMPC - HMGU

skeleton

short tibia ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - HMGU

decreased total retina thickness ( J:211773 )

♀

IMPC - HMGU