Phenotypes Associated with This Genotype

Genotype
MGI:6408543

• Allelic Composition: Nub1^{tm1b(EUCOMM)Hmgu}/Nub1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Nub1^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0664_6_C08

Data Sources

IMPC Data for Nub1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased freezing behavior ( J:211773 )

♀

IMPC - CCP-IMG

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - CCP-IMG

abnormal retina blood vessel morphology ( J:211773 )

IMPC - CCP-IMG

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

increased heart atrium size ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

decreased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased NK cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD5-positive Ly6C-positive T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased Ly6C-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD4-negative NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased Ly6C-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♂

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

homeostasis/metabolism

decreased circulating iron level ( J:211773 )

IMPC - CCP-IMG

increased circulating potassium level ( J:211773 )

♂

IMPC - CCP-IMG

immune system

immune system phenotype ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased NK cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD5-positive Ly6C-positive T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased Ly6C-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased CD4-negative NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

decreased Ly6C-positive NK T cell number ( J:211773 )

♂

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♂

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - CCP-IMG

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - CCP-IMG

abnormal lens morphology ( J:211773 )

IMPC - CCP-IMG

abnormal retina morphology ( J:211773 )

♀

IMPC - CCP-IMG

abnormal retina vasculature morphology ( J:211773 )

IMPC - CCP-IMG

abnormal retina blood vessel morphology ( J:211773 )

IMPC - CCP-IMG