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Phenotypes Associated with This Genotype
Genotype
MGI:6405698
Allelic
Composition
Myo7atm1b(EUCOMM)Wtsi/Myo7atm1b(EUCOMM)Wtsi
Genetic
Background
B6J.Cg-Myo7atm1b(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7atm1b(EUCOMM)Wtsi mutation (0 available); any Myo7a mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• mice show near complete loss of both inner and outer hair cells in the middle and basal cochlear regions
• mice show reduced stria vascularis thickness or atrophy in the basal cochlea
• degeneration of cochlear structure
• however, vestibular hair cells are preserved in 5 month old mice
• males and females exhibit profound hearing loss across all frequencies

vision/eye
• eyes do not dilate as quickly as controls
• scotopic and photopic amplitudes are only modestly reduced after 1 month of age and are reduced by about 20% by 6 months
• however, no gross structural changes are seen in the retina, with normal outer nuclear layer thickness
• scotopic a-wave amplitude is modestly reduced after 2 months of age
• scotopic and photopic b-wave amplitudes are modestly reduced after 2 months of age

behavior/neurological
• eyes do not dilate as quickly as controls

nervous system
• mice show near complete loss of both inner and outer hair cells in the middle and basal cochlear regions
• mice show near complete loss of spiral ganglion neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Usher syndrome type 1 DOID:0110826 OMIM:276900
J:283233


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory