Phenotypes Associated with This Genotype

Genotype
MGI:6404451

• Allelic Composition: Ezhip^em1Marg/Ezhip^em1Marg
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased primordial ovarian follicle number ( J:281161 )

♀ • older females (16 weeks) show a reduction in primordial follicle number and total follicle number indicating a progressive, age related, exhaustion of primordial follicle reserve

♀ • however, no differences are seen in the number of primordial, primary, and secondary/antral follicles of pre-pubertal females

small ovary ( J:281161 )

♀ • ovaries appear smaller

♀ • however, uterine horns appear normal

decreased ovary weight ( J:281161 )

♀ • ovary weight is reduced by about 30%

early reproductive senescence ( J:281161 )

♀ • total number of pups obtained from females decrease each month as females age

reduced female fertility ( J:281161 )

♀ • females give birth to only one litter over a period of 20 weeks compared to 3 litters for wild-type females, with fewer pups than in wild-type

decreased litter size ( J:281161 )

♀ • females give birth to an average of 3 to 4 pups per litter compared to 8 pups per litter for wild-type

mortality/aging

early reproductive senescence ( J:281161 )

♀ • total number of pups obtained from females decrease each month as females age

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:281161 )

♀ • older females (16 weeks) show a reduction in primordial follicle number and total follicle number indicating a progressive, age related, exhaustion of primordial follicle reserve

♀ • however, no differences are seen in the number of primordial, primary, and secondary/antral follicles of pre-pubertal females

small ovary ( J:281161 )

♀ • ovaries appear smaller

♀ • however, uterine horns appear normal

decreased ovary weight ( J:281161 )

♀ • ovary weight is reduced by about 30%