Phenotypes Associated with This Genotype

Genotype
MGI:6403910

• Allelic Composition: Tg(Nes-cre)1Wme/Tg(Nes-cre)1Wme
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112466 )

• all mice die within 5 weeks

nervous system

increased neuron apoptosis ( J:112466 )

• in the developing cortex and cerebellum at E19.5 and P2

abnormal neuronal precursor cell migration ( J:112466 )

• fewer reach the cortical plate

decreased neuronal precursor proliferation ( J:112466 )

• at P2

hydrocephaly ( J:112466 )

• in all mice within the first month of age

non-obstructive hydrocephaly ( J:112466 )

• secondary to the reduction in neural progenitors

decreased brain size ( J:112466 )

• at P2

• in all mice within the first month of age

enlarged brain ventricles ( J:112466 )

• at E19.5, the area occupied by the ventricle is 8-fold compared with wild-type mice

decreased dentate gyrus size ( J:112466 )

• small and disorganized

abnormal cerebral cortex morphology ( J:112466 )

• thin with disorganized layers at P8

• however, no defects are observed in the choroid plexus

thin cerebral cortex ( J:112466 )

• severely at P8

small cerebellum ( J:112466 )

• underdeveloped

abnormal axon morphology ( J:112466 )

• loss and disorganization of myelinated axons at P18

decreased neuron number ( J:112466 )

• in the cortex

growth/size/body

decreased birth body size ( J:112466 )

postnatal growth retardation ( J:112466 )

behavior/neurological

tremors ( J:112466 )

impaired balance ( J:112466 )

abnormal locomotor behavior ( J:112466 )

spasticity ( J:112466 )

cellular

aneuploidy ( J:112466 )

• in the brain of E12.5 embryo

increased neuron apoptosis ( J:112466 )

• in the developing cortex and cerebellum at E19.5 and P2

abnormal neuronal precursor cell migration ( J:112466 )

• fewer reach the cortical plate

decreased neuronal precursor proliferation ( J:112466 )

• at P2