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Phenotypes Associated with This Genotype
Genotype
MGI:6403689
Allelic
Composition		 Apctm1Tno/Apc+
Brf1tm1Arte/Brf1tm1Arte
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (5 available); any Apc mutation (151 available)
Brf1tm1Arte mutation (0 available); any Brf1 mutation (24 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• mice develop similar tumor number and size as in Apctm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• mice develop similar tumor number and size as in Apctm1aTno Tg(Cyp1a1-cre)1Dwi heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory