Phenotypes Associated with This Genotype

Genotype
MGI:6403498

• Allelic Composition: Mexis^tm1.1Pton/Mexis^tm1.1Pton
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased macrophage derived foam cell number ( J:264834 )

• increased number of peritoneal macrophage-derived foam cells

hematopoietic system

increased macrophage derived foam cell number ( J:264834 )

• increased number of peritoneal macrophage-derived foam cells

homeostasis/metabolism

abnormal lipid homeostasis ( J:264834 )

• elevated cholesterol content in peritoneal macrophages when fed Western diet

• normal plasma cholesterol and triglyceride levels when fed Western or chow diet

increased cholesterol level ( J:264834 )

• elevated cholesterol content in peritoneal macrophages when fed Western diet

• circulating cholesterol level

decreased cholesterol efflux ( J:264834 )

• decrease in ApoA-I-dependent efflux capacity in peritoneal macrophages

• cholesterol uptake

immune system

increased macrophage derived foam cell number ( J:264834 )

• increased number of peritoneal macrophage-derived foam cells