Phenotypes Associated with This Genotype

Genotype
MGI:6402831

• Allelic Composition: Tg(CAG-ACE2)AC63Ctkt/0
• Genetic Background: either: (involves: BALB/c * C3H/HeJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6 * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:117824 )

• mice show increased susceptibility to infection with the Urbani strain of the severe acute respiratory syndrome coronavirus (SARS-CoV) than controls, showing a moderate but progressive weight loss until day 8, however all mice recover

• mice infected with a higher dose of SARS-CoV show progressive weight loss and clinical manifestations between day 3 and 4, with much higher viral titer in the lungs and low titers in the brain, however show signs of recovery between day 8 and 9 and completely recover in the ensuing month