Phenotypes Associated with This Genotype

Genotype
MGI:6401463

• Allelic Composition: Ddx41^tm1.1Arte/Ddx41^tm1.1Arte; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:265023 )

N • normal percentage dendritic cells (DCs) in peripheral blood

N • normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

immune system

immune system phenotype ( J:265023 )

N • normal percentage dendritic cells (DCs) in peripheral blood

N • normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

increased susceptibility to Retroviridae infection ( J:265023 )

• lack of interferon beta surge in BMDCs from MLV (murine leukemia virus) or HIV-infected mice

• 5x higher virus titer in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)

• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)

• normal interferon beta surge in bone marrow-derived macrophages (BMDMs) from MLV (murine leukemia virus)-infected mice