Phenotypes Associated with This Genotype

Genotype
MGI:6401219

• Allelic Composition: Rhoa^tm1.1Tpal/Rhoa⁺; Tg(Cd4-cre/ERT2)11Gnri/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:257764 )

• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs

increased T follicular helper cell number ( J:257764 )

• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization

increased regulatory T cell number ( J:257764 )

• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)

• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected

hematopoietic system

increased T cell proliferation ( J:257764 )

• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs

increased T follicular helper cell number ( J:257764 )

• tamoxifen-treated non-immunized mice show increased numbers of CXCR5+ PD1+ T follicular helper cells (Tfh) cells and BCL6+ CXCR5+ Tfh cells indicating induction of Tfh cell polarization

increased regulatory T cell number ( J:257764 )

• tamoxifen-treated non-immunized mice show increased numbers of FOXP3+ CD25+ T regulatory (Treg) cells and FOXP3+ CXCR5+ T follicular helper regulatory cells (Tfr)

• however, differentiation of IFNG+ T helper 1 cells is not affected upon tamoxifen-treatment and generation of CD4+ and CD8+ cells in the thymus is unaffected

cellular

increased T cell proliferation ( J:257764 )

• CD4+ T cells from tamoxifen-treated mice show increased proliferation when stimulated with anti-CD3 plus anti-CD28 antibodies and with anti-CD3 antibody in the presence of iAPCs