Phenotypes Associated with This Genotype

Genotype
MGI:6401150

• Allelic Composition: Mef2b^tm2Rdf/Mef2b⁺; Tg(Cr2-cre)3Cgn/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

immune system

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

enlarged mesenteric lymph nodes ( J:265465 )

• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

enlarged lymph nodes ( J:265465 )

• in 28% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

neoplasm

increased B cell derived lymphoma incidence ( J:265465 )

• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

growth/size/body

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)