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Phenotypes Associated with This Genotype
Genotype
MGI:6401150
Allelic
Composition		 Mef2btm2Rdf/Mef2b+
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (20 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)

immune system
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
enlarged mesenteric lymph nodes ( J:265465 )
• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
enlarged lymph nodes ( J:265465 )
• in 28% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

neoplasm
increased B cell derived lymphoma incidence ( J:265465 )
• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

growth/size/body
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory