Phenotypes Associated with This Genotype

Genotype
MGI:6393536

• Allelic Composition: Vstm4^em1Gypk/Vstm4^em1Gypk
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:285234 )

• mice show a decrease in retinal vasculature area at 12 months, but not 2 months, of age

• however, artery/vein diameter ratios in the retina are not different at 4-6 months of age, indicating no retina artery narrowing or vascular deficit

abnormal induced retina neovascularization ( J:285234 )

• P17 mice subjected to oxygen-induced retinopathy exhibit a higher vascular obliteration than wild-type mice and decreased neovascularization

homeostasis/metabolism

increased susceptibility to injury ( J:285234 )

• P17 mice subjected to oxygen-induced retinopathy exhibit a higher vascular obliteration than wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:285234 )

• mice show a decrease in retinal vasculature area at 12 months, but not 2 months, of age

• however, artery/vein diameter ratios in the retina are not different at 4-6 months of age, indicating no retina artery narrowing or vascular deficit

abnormal induced retina neovascularization ( J:285234 )

• P17 mice subjected to oxygen-induced retinopathy exhibit a higher vascular obliteration than wild-type mice and decreased neovascularization