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Phenotypes Associated with This Genotype
Genotype
MGI:6393456
Allelic
Composition
Spasttm1.1Evre/Spasttm1.1Evre
Genetic
Background
C57BL/6-Spasttm1.1Evre
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spasttm1.1Evre mutation (0 available); any Spast mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are lighter at 1 year of age

behavior/neurological
• gait abnormalities are seen at 4 months and 1 year of age
• mice show a lengthened mean stride duration, almost entirely due to elongation of the swing phase of gait
• however, mice have a symmetrical gait
• mice show increased mean stride length

nervous system
• axon swellings of primary cortical neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spastic paraplegia 4 DOID:0110792 OMIM:182601
J:253467


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory