Phenotypes Associated with This Genotype

Genotype
MGI:6393316

• Allelic Composition: 9030622O22Rik^em1Eem/9030622O22Rik⁺; Foxa2^tm1.1Khk/Foxa2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

respiratory system inflammation ( J:284174 )

• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells

• inflammation is most notable in the subepithelial region of airway branch points

• CD3e+ T cells are found interspersed among the B cells at foci of inflammation

respiratory system

respiratory system inflammation ( J:284174 )

• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells

• inflammation is most notable in the subepithelial region of airway branch points

• CD3e+ T cells are found interspersed among the B cells at foci of inflammation

abnormal respiratory mucosa goblet cell morphology ( J:284174 )

• goblet cell metaplasia, with greater numbers of goblet cells than in single Foxa2 heterozygotes