Phenotypes Associated with This Genotype

Genotype
MGI:6392888

• Allelic Composition: 9030622O22Rik^em1Eem/9030622O22Rik^em1Eem
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

lung inflammation ( J:284174 )

• areas of peribronchial inflammation are seen by 1 year of age

abnormal respiratory mucosa goblet cell morphology ( J:284174 )

• goblet cell metaplasia is seen by 1 year of age, but not at 8-12 weeks of age

homeostasis/metabolism

increased susceptibility to injury ( J:284174 )

• mice show defects in regeneration of the airway epithelium after injury with naphthalene, including incomplete re-epithelialization of the lung airways, peribronchial and perivascular inflammation, goblet cell metaplasia

immune system

lung inflammation ( J:284174 )

• areas of peribronchial inflammation are seen by 1 year of age