Analysis Tools
renal/urinary system
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show larger tubule dilations
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homeostasis/metabolism
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• mice treated with Dox at P0 show elevated blood urea nitrogen levels
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show no differences in blood urea nitrogen levels
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growth/size/body
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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