Phenotypes Associated with This Genotype

Genotype
MGI:6392317

• Allelic Composition: Tulp3^{tm1c(EUCOMM)Hmgu}/Tulp3^{tm1c(EUCOMM)Hmgu}; Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:284006 )

• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts

• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts

• however, blood urea nitrogen levels are normal in Dox treated mice

dilated renal tubule ( J:284006 )

• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show a modest kidney phenotype, with mild tubule dilatations

growth/size/body

kidney cyst ( J:284006 )

• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts

• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts

• however, blood urea nitrogen levels are normal in Dox treated mice