mortality/aging
|
• mutants die around E14.5
|
craniofacial
|
• craniofacial defects at E14.5
|
embryo
|
• open neural tube at E14.5
|
homeostasis/metabolism
limbs/digits/tail
polydactyly
(
J:284006
)
nervous system
|
• open neural tube at E14.5
|
skeleton
|
• severe skeletal defects
|


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