mortality/aging
• mutants die around E14.5
|
craniofacial
• craniofacial defects at E14.5
|
embryo
• open neural tube at E14.5
|
homeostasis/metabolism
limbs/digits/tail
polydactyly
(
J:284006
)
nervous system
• open neural tube at E14.5
|
skeleton
• severe skeletal defects
|