Phenotypes Associated with This Genotype

Genotype
MGI:6392043

• Allelic Composition: Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:283435 )

• premature death at 15 to 30 weeks of age

renal/urinary system

increased mesangial cell number ( J:283435 )

increased urine protein level ( J:283435 )

• severe starting at 2 months of age

podocyte foot process effacement ( J:283435 )

• however, blood capillaries and fenestration of the endothelium are unchanged

glomerulosclerosis ( J:283435 )

renal cast ( J:283435 )

• in the renal tubules

growth/size/body

weight loss ( J:283435 )

• starting at 10 weeks of age

homeostasis/metabolism

increased urine protein level ( J:283435 )

• severe starting at 2 months of age

cellular

increased mesangial cell number ( J:283435 )