Phenotypes Associated with This Genotype

Genotype
MGI:6388689

• Allelic Composition: Orc1^tm1.1Gle/Orc1^tm1.1Gle
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

polyploidy ( J:272584 )

• mouse embryonic fibroblasts (MEFs) infected with a Cre-expressing retrovirus accumulate greater than 2C DNA content

absent fibroblast proliferation ( J:272584 )

• MEFs infected with a Cre-expressing retrovirus cease to proliferate and show negligible BrdU incorporation relative to control MEFs

decreased DNA replication ( J:272584 )

• MEFs infected with a Cre-expressing retrovirus exhibit a block in DNA replication leading to S-phase arrest

homeostasis/metabolism

decreased DNA replication ( J:272584 )

• MEFs infected with a Cre-expressing retrovirus exhibit a block in DNA replication leading to S-phase arrest