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Phenotypes Associated with This Genotype
Genotype
MGI:6388459
Allelic
Composition		 Ngftm1Gne/Ngf+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngftm1Gne mutation (1 available); any Ngf mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:282017 )
• mice exhibit impaired object recognition memory
• however, exploratory behavior is unaffected
impaired spatial learning ( J:282017 )
• mice exhibit delayed learning in the Morris water maze

nervous system
abnormal cholinergic neuron morphology ( J:282017 )
• density of ChAT+ neurons in the medial septum and striatum are decreased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory