Phenotypes Associated with This Genotype

Genotype
MGI:6386322

• Allelic Composition: Arl3^{Gt(EUCJ0159b07)1.1Hmgu}/Arl3^{Gt(EUCJ0159b07)1.1Hmgu}; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein

short photoreceptor outer segment ( J:232436 )

• absent in the central retina with a lack of ciliogenesis

• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein

retina cone cell degeneration ( J:232436 )

• at P15

retina rod cell degeneration ( J:232436 )

• at P15

retina degeneration ( J:232436 )

• at 2 month with no response to light

abnormal cone electrophysiology ( J:232436 )

• reduced at P15 and further at 1 month

abnormal rod electrophysiology ( J:232436 )

• reduced at P15 and further at 1 month

behavior/neurological

decreased optokinetic reflex ( J:232436 )

• reduced at 1 month and nearly extinguished at 2 months

nervous system

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein

short photoreceptor outer segment ( J:232436 )

• absent in the central retina with a lack of ciliogenesis

• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein

retina cone cell degeneration ( J:232436 )

• at P15

retina rod cell degeneration ( J:232436 )

• at P15

cellular

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein