Phenotypes for A1cf Hspd1 MGI:6385859 MGI Mouse

premature death ( J:283049 )

• all mice die within 14 weeks post tamoxifen injection

enlarged heart ( J:283049 )

• mice show enlarged hearts 11 weeks post tamoxifen injection

abnormal heart ventricles weight ( J:283049 )

• ratio of ventricular weight to body weight is increased at 11 weeks post tamoxifen injection

thin ventricular wall ( J:283049 )

• ventricular wall thinning is seen at 11 weeks post tamoxifen injection

dilated heart ventricle ( J:283049 )

• ventricular chamber dilation is seen at 11 weeks post tamoxifen injection

cardiac fibrosis ( J:283049 )

• hearts show severe cardiac fibrosis at 11 weeks post tamoxifen injection

abnormal cardiovascular system physiology ( J:283049 )

• increase in number of apoptotic cells is seen in hearts at 11 weeks post tamoxifen injection

dilated cardiomyopathy ( J:283049 )

• mice develop dilated cardiomyopathy after tamoxifen injection

decreased heart left ventricle muscle contractility ( J:283049 )

• left ventricle fractional shortening and ejection fraction are slightly decreased at 9 weeks and further decreased at 11 and 13 weeks after tamoxifen injection

abnormal heart echocardiography feature ( J:283049 )

• left ventricle systolic function represented by fractional shortening and ejection fraction is slightly decreased at 9 weeks post tamoxifen injection and further increased at 11 and 13 weeks after tamoxifen injection

• enlarged left ventricle chamber and ventricular wall thinning are seen at 11 and 13 weeks after tamoxifen injection

• left ventricle systolic function further deteriorates at 11 and 13 weeks after tamoxifen injection

• however, ventricular wall thickness and internal dimension of the heart are not altered at 9 weeks post tamoxifen injection

congestive heart failure ( J:283049 )

• mice develop dilated cardiomyopathy and heart failure after tamoxifen injection

abnormal mitochondrial physiology ( J:283049 )

• activities of complex I and complex III in mitochondria are impaired at 9 weeks post tamoxifen injection

• activities of all four complexes in mitochondria are impaired at 11 weeks post tamoxifen injection

• cardiomyocytes show reduced mitochondrial potential and increased mitochondrial ROS levels at 9 weeks post tamoxifen injection

oxidative stress ( J:283049 )

• cardiomyocytes show increased mitochondrial ROS levels at 9 weeks post tamoxifen injection