Phenotypes Associated with This Genotype

Genotype
MGI:6383926

• Allelic Composition: Ncam1^tm1Cgn/Ncam1^tm1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina ganglion cell number ( J:235028 )

• at 18 months

• however, the number of optic nerve axons is normal at 2 and 18 months

increased retina ganglion cell number ( J:235028 )

• at 2 months

• however, the number of optic nerve axons is normal at 2 and 18 months

thick retina ganglion layer ( J:235028 )

• in middle and peripheral regions at 2 months

thin retina inner nuclear layer ( J:235028 )

• at 18 months

thick retina inner plexiform layer ( J:235028 )

• increased at 2 months

thin retina outer nuclear layer ( J:235028 )

• loss of one third of thickness in the central areas at 18 months

thin retina outer plexiform layer ( J:235028 )

• at 18 months

abnormal total retina thickness ( J:235028 )

• increased retinal thickness only in the peripheral temporal region at 2 months

• reduced retinal thickness in the central areas at 18 months

• however, mice exhibit normal thickness in the inner nuclear layer, outer plexiform layer and outer nuclear layer at 2 months

abnormal rod electrophysiology ( J:235028 )

• a-wave Vmax is more than double wild-type before falling to normal levels by 10 months and older

• b-wave V-max is more than double at 2 months then falls to normal levels by 10 months or older with premature loss of light sensitivity at 18 months

• however, mice exhibit normal retinal sensitivity and b-wave to a-wave ratio

abnormal vision ( J:235028 )

• premature loss of visual detection

• no ability to detect pattern at any age

decreased visual acuity ( J:235028 )

• premature

nervous system

decreased retina ganglion cell number ( J:235028 )

• at 18 months

• however, the number of optic nerve axons is normal at 2 and 18 months

increased retina ganglion cell number ( J:235028 )

• at 2 months

• however, the number of optic nerve axons is normal at 2 and 18 months