Phenotypes Associated with This Genotype

Genotype
MGI:6382796

• Allelic Composition: Sod1^tm1Leb/Sod1^tm1Leb
• Genetic Background: involves: 129S7/SvEvBrd-Hprt^b-m2 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

thin retina inner nuclear layer ( J:134267 )

• progressive age-related thinning from age 30 weeks

disorganized retina inner nuclear layer ( J:134267 )

• swollen nuclei, vacuolized cytoplasm and disrupted plasma and nuclear membranes in 15-month-old senescent mice

thin retina outer nuclear layer ( J:134267 )

• progressive age-related thinning from age 30 weeks

disorganized retina outer nuclear layer ( J:134267 )

• decreased density, swollen cell bodies and damaged mitochondria in 15-month-old senescent mice

decreased a-wave amplitude ( J:134267 )

• with scotopic and photopic ERG at age 42 and 81 weeks

decreased b-wave amplitude ( J:134267 )

• with scotopic and photopic ERG at age 42 and 81 weeks