Phenotypes Associated with This Genotype

Genotype
MGI:6382623

• Allelic Composition: Tg(Dkk3-cre)D9Tfur/0; Top2b^tm2Jcw/Top2b^tm2Jcw
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal photoreceptor outer segment morphology ( J:282250 )

• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS

photoreceptor outer segment degeneration ( J:282250 )

• virtually no OS by age P14

abnormal retina cone cell morphology ( J:282250 )

• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14

abnormal retina cone cell outer segment morphology ( J:282250 )

• shorter neural processes on s-cones at age P0

• no neural processes on s-cones at age P7 and P14

abnormal retina rod cell morphology ( J:282250 )

• outer nuclear layer cells intrude into inner nuclear layer at age P14

abnormal retina rod cell outer segment morphology ( J:282250 )

• elimination or significant reduction of rhodopsin signal at age P7 and P14

retina photoreceptor degeneration ( J:282250 )

• increased apoptosis in outer nuclear layer at age P7, P14 and P21

retina cone cell degeneration ( J:282250 )

• by age P14

abnormal retina pigment epithelium morphology ( J:282250 )

• retina detached from RPE at age P14 and P21 owing to absence of outer segment

thin retina outer nuclear layer ( J:282250 )

• at age P7 and P14

abnormal retina outer plexiform layer morphology ( J:282250 )

• absent at age P7, P14 and P21

abnormal retina outer limiting membrane morphology ( J:282250 )

• elimination or significant reduction of rhodopsin signal at age P7 and P14

nervous system

abnormal photoreceptor outer segment morphology ( J:282250 )

• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS

photoreceptor outer segment degeneration ( J:282250 )

• virtually no OS by age P14

abnormal retina cone cell morphology ( J:282250 )

• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14

abnormal retina cone cell outer segment morphology ( J:282250 )

• shorter neural processes on s-cones at age P0

• no neural processes on s-cones at age P7 and P14

abnormal retina rod cell morphology ( J:282250 )

• outer nuclear layer cells intrude into inner nuclear layer at age P14

abnormal retina rod cell outer segment morphology ( J:282250 )

• elimination or significant reduction of rhodopsin signal at age P7 and P14

retina photoreceptor degeneration ( J:282250 )

• increased apoptosis in outer nuclear layer at age P7, P14 and P21

retina cone cell degeneration ( J:282250 )

• by age P14

pigmentation

abnormal retina pigment epithelium morphology ( J:282250 )

• retina detached from RPE at age P14 and P21 owing to absence of outer segment