Phenotypes Associated with This Genotype

Genotype
MGI:6382538

• Allelic Composition: C3ar1^tm1Cge/C3ar1^tm1Cge
• Genetic Background: B6.129S4(C)-C3ar1^tm1Cge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

thin retina inner nuclear layer ( J:214214 )

• the inner nuclear layer is thinner at 3 and 14 months of age

thin retina outer nuclear layer ( J:214214 )

• outer nuclear layer thinning is seen at older ages

disorganized retina outer nuclear layer ( J:214214 )

• the outer nuclear layer is disorganized at 3 months of age

increased susceptibility to age-related retinal degeneration ( J:214214 )

• mice show progressive retinal cell loss

decreased a-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age

• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased a-wave amplitude

decreased b-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age

• after an 8-hour light exposure, mice show a greater loss of retinal function than wild-type mice, showing decreased b-wave amplitude

abnormal c-wave shape ( J:214214 )

• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age

• however, no other component of the dc-ERG is different

nervous system

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

homeostasis/metabolism

decreased circulating free fatty acids level ( J:214214 )

• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

decreased circulating phospholipid level ( J:214214 )

• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular

increased retina apoptosis ( J:214214 )

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months