Phenotypes Associated with This Genotype

Genotype
MGI:6382193

• Allelic Composition: Rara^tm1Ipc/Rara⁺; Rarb^tm1Ipc/Rarb⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal alisphenoid bone morphology ( J:21009 )

• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod

abnormal incus morphology ( J:21009 )

• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone

abnormal incus short process morphology ( J:21009 )

• larger than in wild-type mice

endocrine/exocrine glands

abnormal Harderian gland development ( J:21009 )

• bilateral absence of the epithelial rudiments of all intraorbital glands (including lachrymal and Harderian glands) in all mice at E18.5

• however, the stroma is present

hearing/vestibular/ear

abnormal incus morphology ( J:21009 )

• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone

abnormal incus short process morphology ( J:21009 )

• larger than in wild-type mice

limbs/digits/tail

short fibula ( J:21009 )

• severe in one mouse, milder in two mice

skeleton

abnormal alisphenoid bone morphology ( J:21009 )

• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod

abnormal incus morphology ( J:21009 )

• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone

abnormal incus short process morphology ( J:21009 )

• larger than in wild-type mice

short fibula ( J:21009 )

• severe in one mouse, milder in two mice

vision/eye

absent nasolacrimal duct ( J:21009 )

• in all mice