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Phenotypes Associated with This Genotype
Genotype
MGI:6379623
Allelic
Composition		 Tg(Myl1-Trp53inp2)2Azo/0
Genetic
Background		 involves: C57BL/6J
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
enhanced autophagy ( J:212763 )
• males show a reduction of LC3I protein and increased LC3II/LC3I ratio indicating enhanced autophagy

growth/size/body
decreased lean body mass ( J:212763 )
• lean tissue volume is reduced in 4 month old mice

homeostasis/metabolism
enhanced autophagy ( J:212763 )
• males show a reduction of LC3I protein and increased LC3II/LC3I ratio indicating enhanced autophagy

muscle

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory