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Phenotypes Associated with This Genotype
Genotype
MGI:6378625
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-PTPN1,-EGFP)Mtr/Gt(ROSA)26Sor+
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-PTPN1,-EGFP)Mtr mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
prostate gland anterior lobe hyperplasia ( J:231906 )
• mice show a moderate incidence of epithelial hyperplasia in the anterior prostate
increased prostate intraepithelial neoplasia incidence ( J:231906 )
• one mouse shows a prostatic intraepithelial neoplasia (mPIN) in the dorsolateral prostate

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:231906 )
• one mouse shows a prostatic intraepithelial neoplasia (mPIN) in the dorsolateral prostate

reproductive system
prostate gland anterior lobe hyperplasia ( J:231906 )
• mice show a moderate incidence of epithelial hyperplasia in the anterior prostate
increased prostate intraepithelial neoplasia incidence ( J:231906 )
• one mouse shows a prostatic intraepithelial neoplasia (mPIN) in the dorsolateral prostate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory