Phenotypes Associated with This Genotype

Genotype
MGI:6376184

• Allelic Composition: Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Trit1^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 13142A-H7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Trit1^{tm1.1(KOMP)Vlcg}/Trit1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with fewer than expected number of embryos at E7.5 and no embryos at E9.5. Though an egg cyclinder is formed, no morphological node or other hallmarks typical of E7.5 are present.

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:279207 )

• although normal blastocysts are present in expected Mendelian ratios at E3.5, very few homozygous embryos can be recovered at E7.5 (7% vs expected 25%, n=43)

• in vitro, blastocysts hatch from the zona pellucida and form fairly normal outgrowth colonies after 3 days in culture

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• no homozygous embryos are identified at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• although an egg cylinder has formed, no morphological node or other hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no morphological node is present at E7.5