Phenotypes Associated with This Genotype

Genotype
MGI:6369091

• Allelic Composition: Lamtor5^tm1Lye/Lamtor5^tm1Lye; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:258406 )

• insulin content in isolated islets is decreased

decreased insulin secretion ( J:258406 )

• islets exhibit a decrease in glucose-stimulated insulin secretion that is more profound in islets from high-fat diet fed mice

homeostasis/metabolism

decreased insulin secretion ( J:258406 )

• islets exhibit a decrease in glucose-stimulated insulin secretion that is more profound in islets from high-fat diet fed mice

increased fasting circulating glucose level ( J:258406 )

• mice exhibit higher blood glucose levels in fasting conditions on both a normal chow diet and high-fat diet

decreased circulating insulin level ( J:258406 )

• both chow diet and high-fat diet fed mice show decreased circulating insulin levels

impaired glucose tolerance ( J:258406 )

• both chow diet and high-fat diet fed mice develop glucose intolerance upon intraperitoneal glucose administration, which is exacerbated when mice are obese

• however, mice exhibit normal insulin sensitivity

growth/size/body

growth/size/body region phenotype ( J:258406 )

N • mice exhibit normal body weight gain, food intake on a high-fat diet, and normal liver mass either on a normal chow diet or high fat diet