Phenotypes Associated with This Genotype

Genotype
MGI:6368112

• Allelic Composition: \Apmap^{tm1a(KOMP)Wtsi}/\Apmap^{tm1a(KOMP)Wtsi}; \Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0133_1_G06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial reference memory ( J:273177 )

• in a simplified Morris water maze test, 20-month-old mice show a more severe spatial memory deficit with poorer escape learning during training trials and significantly less time spent in the target quadrant during the probe trial relative to age-matched transgenic mice wild-type for Apmap

nervous system

amyloid beta deposits ( J:273177 )

• 9-month-old mice show a 20 +/- 4 % increase in cerebral Abeta1-40 peptide levels associated with a 24 +/- 5 % increase in the hippocampal Abeta plaque area relative to age-matched transgenic mice wild-type for Apmap

homeostasis/metabolism

amyloid beta deposits ( J:273177 )

• 9-month-old mice show a 20 +/- 4 % increase in cerebral Abeta1-40 peptide levels associated with a 24 +/- 5 % increase in the hippocampal Abeta plaque area relative to age-matched transgenic mice wild-type for Apmap