Phenotypes for Mirc33 Ppargc1a MGI:6367623 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi Ppargc1a^tm1Brsp/Ppargc1a⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc33^tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)
Ppargc1a^tm1Brsp mutation (1 available); any Ppargc1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• mice exhibit a life span extension compared with single Mirc33^tm1.1Wtsi homozygotes, with a median of 39.5 weeks compared to 30 weeks, but reduced survival compared to wild-type mice

cellular

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller

• however, cardiac mitochondrial DNA levels and mitochondrial numbers are restored to wild-type levels

cardiovascular system

cardiovascular system phenotype ( J:267719 )

N	• mice show a reduction in systemic blood pressure compared to single Mirc33^tm1.1Wtsi homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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