Phenotypes Associated with This Genotype

Genotype
MGI:6367565

• Allelic Composition: Gata6os^em1Zfa/Gata6os^em1Zfa; Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system development ( J:268724 )

• reduced intestinal stem cells with impaired organoid formation capacity

• however, overexpression of Ehf rescues this phenotype

abnormal crypts of Lieberkuhn morphology ( J:268724 )

• short with fewer cells than in wild-type mice

abnormal small intestinal villus morphology ( J:268724 )

• short with fewer cells than in wild-type mice

abnormal enterocyte physiology ( J:268724 )

• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:268724 )

• short with fewer cells than in wild-type mice

homeostasis/metabolism

abnormal response to radiation ( J:268724 )

• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice