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Phenotypes Associated with This Genotype
Genotype
MGI:6363420
Allelic
Composition
Rtbdntm1.1Itl/Rtbdn+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtbdntm1.1Itl mutation (0 available); any Rtbdn mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P240, but not at P60, mice show a ~23% reduction in the number of cone photoreceptor cells relative to wild-type controls
• at P240, but not at P60, mice show a ~19.9% reduction in the number of rod photoreceptor cells relative to wild-type controls
• at P240, mice show a ~23% reduction in scotopic a-wave amplitude relative to wild-type controls
• however, no significant changes are observed at P120
• at P240, mice show a ~20% reduction in photopic b-wave amplitude relative to wild-type controls
• however, no significant changes are observed at P120

nervous system
• at P240, but not at P60, mice show a ~23% reduction in the number of cone photoreceptor cells relative to wild-type controls
• at P240, but not at P60, mice show a ~19.9% reduction in the number of rod photoreceptor cells relative to wild-type controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory