Phenotypes Associated with This Genotype

Genotype
MGI:6363124

• Allelic Composition: Pbxip1^tm1Cya/Pbxip1^tm1Cya; Tg(Col2a1-cre/ERT)KA3Smac/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

osteoarthritis ( J:270267 )

• following anterior cruciate ligament transection, tamoxifen-treated mice less severe osteoarthritis with improved trabeculae connectivity and microarchitecture, performance on a rotarod, weight bearing, distance traveled and hotplate withdrawal compared to in wild-type mice

short humerus ( J:270267 )

• in tamoxifen-treated mice

short radius ( J:270267 )

• in tamoxifen-treated mice

short ulna ( J:270267 )

• in tamoxifen-treated mice

short femur ( J:270267 )

• in tamoxifen-treated mice

short tibia ( J:270267 )

• in tamoxifen-treated mice

abnormal long bone epiphyseal plate proliferative zone ( J:270267 )

• expanded in tamoxifen-treated mice

increased width of hypertrophic chondrocyte zone ( J:270267 )

• in tamoxifen-treated mice

short lumbar vertebrae ( J:270267 )

• in tamoxifen-treated mice

growth/size/body

proportional dwarf ( J:270267 )

• mild in tamoxifen-treated mice

homeostasis/metabolism

decreased susceptibility to injury ( J:270267 )

• following anterior cruciate ligament transection, tamoxifen-treated mice less severe osteoarthritis with improved trabeculae connectivity and microarchitecture, performance on a rotarod, weight bearing, distance traveled and hotplate withdrawal compared to in wild-type mice

limbs/digits/tail

short humerus ( J:270267 )

• in tamoxifen-treated mice

short radius ( J:270267 )

• in tamoxifen-treated mice

short ulna ( J:270267 )

• in tamoxifen-treated mice

short femur ( J:270267 )

• in tamoxifen-treated mice

short tibia ( J:270267 )

• in tamoxifen-treated mice

immune system

osteoarthritis ( J:270267 )

• following anterior cruciate ligament transection, tamoxifen-treated mice less severe osteoarthritis with improved trabeculae connectivity and microarchitecture, performance on a rotarod, weight bearing, distance traveled and hotplate withdrawal compared to in wild-type mice