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Phenotypes Associated with This Genotype
Genotype
MGI:6360946
Allelic
Composition
Slc39a8tm1.2Mrl/Slc39a8tm1.2Mrl
Genetic
Background
B6(Cg)-Slc39a8tm1.2Mrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a8tm1.2Mrl mutation (0 available); any Slc39a8 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• hearts exhibit extracellular matrix accumulation at E12.5
• hearts exhibit hypertrabeculation, with a 24.9% increase at E12.5 and 44.2% increase at E14.5
• hearts exhibit thin compact myocardium, with a 53.9% decrease in thickness at E12.5, and 72.7% decrease at E14.5
• hearts exhibit left ventricular noncompaction
• cardiomyocyte proliferation is increased in E12.5 hearts
• however, cardiomyocyte cell death is similar to wild-type levels

homeostasis/metabolism
• some E14.5 mutants exhibit body edema
• zinc levels are lower in E14.5 hearts

cellular
• cardiomyocyte proliferation is increased in E12.5 hearts
• however, cardiomyocyte cell death is similar to wild-type levels

muscle
• hearts exhibit hypertrabeculation, with a 24.9% increase at E12.5 and 44.2% increase at E14.5
• hearts exhibit thin compact myocardium, with a 53.9% decrease in thickness at E12.5, and 72.7% decrease at E14.5
• cardiomyocyte proliferation is increased in E12.5 hearts
• however, cardiomyocyte cell death is similar to wild-type levels

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
left ventricular noncompaction DOID:0060480 OMIM:604169
J:258360


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory