Phenotypes Associated with This Genotype

Genotype
MGI:6360907

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu}; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6N * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N • neonatal mice exhibit normal capillary vessel distribution and endocardium

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

abnormal heart development ( J:273437 )

• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age

thick aortic valve cusps ( J:273437 )

• at P0 and in adult mice

thick pulmonary valve cusps ( J:273437 )

• at P0 and in adult mice

increased heart left ventricle weight ( J:273437 )

cardiac fibrosis ( J:273437 )

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

cellular

decreased apoptosis ( J:273437 )

• reduced apoptosis of endothelial-derived valvar interstitial cells

increased cell proliferation ( J:273437 )

• prolonged cell proliferation of endothelial-derived valvar interstitial cells

muscle

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

growth/size/body

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age