Phenotypes Associated with This Genotype

Genotype
MGI:6360906

• Allelic Composition: Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:273437 )

• all mice die within 14 weeks of birth

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N • at neonatal stages, mitral and tricuspid valves appear normal

abnormal heart development ( J:273437 )

• increased proliferation of valvar interstitial cells in E15.5 heart valves

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• at P1

thick aortic valve cusps ( J:273437 )

• at adult and neonatal stages

aortic valve stenosis ( J:273437 )

thick pulmonary valve cusps ( J:273437 )

• at adult and neonatal stages

abnormal blood flow velocity ( J:273437 )

• increased velocity and pressure gradient across the aortic valves

increased cardiac muscle contractility ( J:273437 )

• increased ejection fraction and fractional shortening

growth/size/body

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• at P1

decreased body size ( J:273437 )

• at P1

decreased body weight ( J:273437 )

• from birth

cellular

increased cell proliferation ( J:273437 )

• increased proliferation of valvar interstitial cells in E15.5 heart valves

muscle

increased cardiac muscle contractility ( J:273437 )

• increased ejection fraction and fractional shortening