Phenotypes Associated with This Genotype

Genotype
MGI:6360703

• Allelic Composition: Odad3^{tm1b(EUCOMM)Hmgu}/Odad3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Odad3^{tm1b(EUCOMM)Hmgu}/Cnrm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:278798 )

• most mice die between the second postnatal week and the post-weaning period

reproductive system

azoospermia ( J:278798 )

♂ • in surviving male mice

nervous system

intracranial hemorrhage ( J:278798 )

• within the cortex

non-obstructive hydrocephaly ( J:278798 )

• severe that is not associated with a discontinuous cerebral aqueduct of Sylvius

increased forebrain size ( J:278798 )

abnormal brain ependyma morphology ( J:278798 )

• the dorsal part of the lateral ventricle lacks the ependyma cell layer, the loss occurs prior to enlargment

enlarged lateral ventricles ( J:278798 )

thin cerebral cortex ( J:278798 )

abnormal cerebellum morphology ( J:278798 )

• cerebellar compression

• however, cerebellar volumes are normal

growth/size/body

postnatal growth retardation ( J:278798 )

• at P6 and more so at P10

situs inversus ( J:278798 )

• in most mice

situs inversus totalis ( J:278798 )

• in most mice

situs inversus with levocardia ( J:278798 )

• in most mice

enlarged spleen ( J:278798 )

• in some mice

hematopoietic system

abnormal spleen morphology ( J:278798 )

• split at the distal end in some mice

• polycystic in some mice

enlarged spleen ( J:278798 )

• in some mice

absent spleen ( J:278798 )

• in some mice with normal situs

cardiovascular system

intracranial hemorrhage ( J:278798 )

• within the cortex

cellular

azoospermia ( J:278798 )

♂ • in surviving male mice

craniofacial

domed cranium ( J:278798 )

liver/biliary system

abnormal liver morphology ( J:278798 )

• inverted in some mice

skeleton

domed cranium ( J:278798 )

immune system

abnormal spleen morphology ( J:278798 )

• split at the distal end in some mice

• polycystic in some mice

enlarged spleen ( J:278798 )

• in some mice

absent spleen ( J:278798 )

• in some mice with normal situs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 30		DOID:0110624	OMIM:616037	J:278798