Phenotypes Associated with This Genotype

Genotype
MGI:6360616

• Allelic Composition: Rhpn1^tm1Ktry/Rhpn1^tm1Ktry; Rhpn2^tm1Ssch/Rhpn2^tm1Ssch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:276466 )

• mice show reduced lifespan

homeostasis/metabolism

increased circulating creatinine level ( J:276466 )

albuminuria ( J:276466 )

• albumin/creatinine ratio is increased

renal/urinary system

albuminuria ( J:276466 )

• albumin/creatinine ratio is increased

glomerulosclerosis ( J:276466 )

• segmental and global glomerular sclerosis

renal interstitial fibrosis ( J:276466 )

• interstitial fibrosis in nephrotic kidneys

dilated renal tubule ( J:276466 )

• tubule dilatation in nephrotic kidneys

renal cast ( J:276466 )

• tubular casts in nephrotic kidneys