Phenotypes Associated with This Genotype

Genotype
MGI:6360558

• Allelic Composition: Tctn3^{tm3(Tctn2)Blnw}/Tctn3^{tm3(Tctn2)Blnw}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SW

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:249241 )

• no embryos are recovered at E13.5, however live embryos are seen at E10.5, indicating lethality at E11.5-E12.5

embryo

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia density in the neural tube is lower, indicating defective ciliogenesis

• however, neural tube pattering is unaffected

cardiovascular system

abnormal direction of heart looping ( J:249241 )

• 6 of 9 embryos develop hearts that loop in the rightward direction, opposite of normal heart looping, indicating randomized hear looping

cellular

abnormal cilium morphology ( J:249241 )

• cilia density in the neural tube is lower, indicating defective ciliogenesis

• percentage of ciliated cells in primary mouse embryo fibroblasts is lower than for wild-type

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia density in the neural tube is lower, indicating defective ciliogenesis

• however, neural tube pattering is unaffected

nervous system

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia density in the neural tube is lower, indicating defective ciliogenesis

• however, neural tube pattering is unaffected

holoprosencephaly ( J:249241 )